Accra Lions look on course to survive in their first campaign in the elite division, as they are currently 10th on the league table and are five points adrift of the drop.
Lions out of their 26 matches played so far have recorded 9 wins, 6 draws, and 10 losses in their debut season.
Hearts of Oak, who are defending champions, trail the top of the table by 15 points, sitting 6th with 37 points, that is 9 wins, 10 draws and 6 losses.
Accra Lions will dwell on their rich home form, which has seen them win their last four matches at the Accra Sports Stadium, while Hearts of Oak will be hoping to rediscover their form.
Hearts key man Sulley Muntari has returned after missing the Phobian's last four games. Sulley has been named among the bench.