Issifu Omoro Tanko Amadu is a Supreme Court judge of the Republic of Ghana. He was appointed the Justice of the High Court between 2008 and 2012. He became an Appeal court judge in 2012.

He was nominated by the president Nana Akufo-Addo. He is the first Muslim to serve on Ghana's Supreme Court.

Issifu was born in Dodowa in the Greater Accra region of Ghana. He attended District Assembly Primary School and Methodist Middle School, both located in Dodowa for his basic education.

He later had his secondary education at Ghanata Senior High School and Ghana Senior High School situated in Koforidua.

He obtained his LLB at the University of Ghana and moved on to the Ghana School of Law for his professional law course. He sojourned in Nigeria before obtaining a professional law course at the Nigeria School of Law.

After gaining some practical experience with Azinyo Chambers located in Accra, he worked with some Nigerian law firms such as A.C Mathews & Co. and later as an Associate Member of Alao Aka Bashorun & Co. both located in Lagos. He worked as a lawyer in Nigeria for nineteen years.

He founded his own firm and became the Principal of Amadu & Co. in 1997 and after the Senior Partner Amadu, Ansah-Obiri & Co.

Issifu was appointed to the High Court in 2008 and was promoted to the Court of Appeal after four years.

He was sworn into office by President Nana Akufo-Addo, in a ceremony at the Jubilee House. His nomination was approved by the Parliament of Ghana with other three judges after they were vetted. The rest were Justice Clemence Jackson Honyenuga, Professor. Henrietta J.A.N Mensa-Bonsu, and Mr. Emmanuel Yonny Kulendi.

He received a Humanity Award from Humanity Magazine International for inspiring Zongo communities in the field of law.