Nana Kwame Ampadu is a Ghanaian musician who is known to have composed over 800 songs.

He formed the African Brothers Band in 1963 with Eddie Donkor as one of the founding members.

In 1963, he released a song, Ebi Te Yie, meaning "Some Are Well Seated" which caused a stir in the country during the then-governing of National Liberation Council. The song subsequently disappeared from the airwaves but returned after the military rule. He won a nationwide competition in 1973 and was named Odwontofoohene.

He composed a song for Jerry John Rawlings and the National Democratic Congress in the 1992 election campaign as well well a song that attempted to disqualify Jerry John Rawlings from the 1992 election because he was half Scottish.

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